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DDIT3 (CHOP) (12q13) Gene Rearrangement by FISH
Ordering Recommendation
Use in conjunction with histologic and clinical information for the diagnosis of round cell/myxoid liposarcoma.
New York DOH Approval Status
Specimen Required
Tumor tissue.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained (4-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™or contact ARUP Client Services at (800) 522-2787 (kit recommended but not required). (Min 2 slides).
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
Fluorescence in situ Hybridization (FISH)
Performed
Mon-Fri
Reported
3-7 days
Reference Interval
By report
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Analyte Specific Reagent (ASR)
Note
Hotline History
CPT Codes
88366
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3000635 | DDIT3 FISH Reference Number | |
| 3000636 | DDIT3 FISH Source | |
| 3000637 | DDIT3 FISH Result | |
| 3000703 | Scoring Method | 81304-8 |
| 3002938 | Total Cell Count | 78236-7 |
Aliases
- CHOP break apart FISH
- CHOP rearrangement FISH
- DDIT3 break-apart FISH
- DDIT3 FISH probe
- DDIT3 rearrangement FISH
- t(12;16) translocation by FISH
- t(12;22)translocation by FISH
